Established in 2018, Shaanxi Bieyouth Biotech Co., Ltd. has developed into a premier golden supplier integrating state-of-the-art biological production and global scale export operations. Leveraging decades of aggregated foreign trade expertise, we lead the domestic market in customizing and manufacturing botanical extracts, advanced food additives, premium cosmetic raw materials, and high-purity pharmaceutical compounds.
Our infrastructure centers around two highly standardized, GMP-certified production facilities equipped with advanced physical extraction and vacuum fractionation technologies. With strategic distribution links worldwide, we deliver raw material security to partners in the United States, the United Kingdom, Canada, Russia, Australia, and beyond.
Execution of a five-level QC/QA program encompassing HPLC screening, solvent verification, heavy metal monitoring, and microbiological assays.
Complete custom formulations, bespoke biological concentrations, and contract private-label packaging configured to your specific regulatory market.
Traditional menthol provides an instant cool feeling but causes sensory fatigue and odors. Our next-gen physiological cooling agents targeted specifically at the TRPM8 (Transient Receptor Potential Melastatin 8) ion channels trigger nerve impulses without lowering physical skin temperatures, providing a longer cooling duration without chemical irritation.
Our WS series (including WS-23, WS-3, and WS-5) utilizes synthetic carboxamide backbones that boast thermal endurance exceeding 200°C. This enables direct application during high-temperature extrusion processes in food processing and confectioneries without volatile loss of cooling intensity.
By micro-encapsulating and blending hydrophobic sensate agents, we manage molecular desorption rates. The result is a dual-phase sensory profile: an immediate cooling burst from surface-active agents followed by a continuous release that lasts for up to 30 minutes in oral care and cosmetics.
Understanding the structural variables of mainstream cooling agents allows formulation chemists to match sensory performance with product matrix polarity.
| Cooling Agent | Chemical Designation | Cooling Intensity (vs Menthol) | Thermal Stability Limit | Olfactory Impact | Recommended Applications |
|---|---|---|---|---|---|
| WS-23 | N,2,3-Trimethyl-2-isopropylbutanamide | 75% - 80% | ~ 220°C | Neutral (Odorless) | Beverages, Chewing Gum, Oral Care, Vape |
| WS-3 | N-Ethyl-p-menthane-3-carboxamide | 150% | ~ 180°C | Slightly minty | Toothpaste, Confectionery, Topical Gels |
| WS-5 | Ethyl 3-(p-menthane-3-carboxamido)acetate | 250% - 300% | ~ 160°C | None | Long-acting cosmetics, high-end pharma |
| Menthyl Lactate | Propanoic acid, 2-hydroxy-, 5-methyl-2-(1-methylethyl)cyclohexyl ester | 40% | ~ 120°C | Mild herbaceous | Anti-aging skincare, sun care, body washes |
Delivers a calming sensation to sun-stressed skin, reduces inflammation discomfort in acne treatments, and provides refreshing sensory cues in shampoos and body washes.
Maintains fresh taste profiles in hard candies, chewing gums, and throat lozenges without modifying core flavor notes. Highly stable in carbonate-charged carbonated beverages.
Blends with silica base toothpastes, alcohol-free mouthwashes, and breath sprays to lengthen the clean feeling after brushing without dry-mouth side effects.
Enhances analgesic efficacy in joint pain rubs, muscle recovery creams, and insect-bite roll-ons through hyper-sensory nerve stimulation.
With an annual manufacturing capacity exceeding 50,000 tons, our automated synthesis lines minimize human error, drive down per-kilo synthesis costs, and guarantee long-term price stability for bulk raw materials contract manufacturing.
Our facility in Shaanxi leverages the proximity to domestic precursor extraction points. This localized botanical and synthetic feedstock access keeps us immune to transcontinental shipping interruptions and logistics spikes.
Every single batch produced at our GMP workshops features a unique digital fingerprint. Complete GC-MS testing data, batch processing timelines, and purity documentation are immediately exportable to client compliance panels.
Participated in the prestigious Shanghai International Cosmetics, Personal Care and Home Care Raw Materials Exhibition (PCHi), introducing customized cooling sensations and green actives directly to key cosmetics chemists.
Officially obtained certification and listing from the United States Food and Drug Administration (FDA) in August 2023, unlocking streamlined trade channels for our food and drug ingredients into the North American market.
Launched wide-scale international operations. Concurrently built the Shaanxi Biology Institute to focus on active skin science, later included in the government's key industrial projects.
Awarded the titles of "Integrity Enterprise" and "Quality Assured Enterprise", setting the baseline for the reliable supply of raw materials globally.
Optimized for anti-fatigue supplements and performance formulations, enhancing cellular energy levels naturally.
Delivers anti-allergy active fractions and deep respiratory health support for functional food applications.
A highly safe, industrial-grade food antioxidant used to stabilize lipid systems against thermal and oxidative degradation.
Pure raw material focused on cardiovascular cellular energy support and mitochondrial antioxidant defense.
In-depth coordination on desired cool feeling duration, solubility limits (water vs glycol), stability benchmarks, and regional compliance needs.
Adjusting the carboxamide configuration (e.g. optimizing WS-23 to WS-3 ratios) or configuring specialized botanical active ratios.
Synthesizing pilot batches for lab testing, organoleptic feedback, and chemical stability verification within your final formulation base.
Transitioning into mass production inside our GMP-certified workshops under continuous, multi-stage chromatographic monitoring.
Secure packaging matching hazardous/non-hazardous chemical requirements, cleared for customs entry into US, EU, and Asia-Pacific markets.
Navigating complex tariff structures, clearance pathways, and customs requirements for global bio-ingredients.
Maintaining clean rooms, air filtration, and sterile packaging systems to keep products micro-contaminant-free.
Bridging the gap between active synthetic efficiency and clean, renewable botanical starting materials.
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1,223 reviews on Trustpilot
Our cooling agents are produced in alignment with the Flavor and Extract Manufacturers Association (FEMA) GRAS guidelines and registered under the EU REACH framework to ensure smooth importation.
We supply full safety data sheets (SDS) matching GHS standards in English, Spanish, and German, along with Certificates of Analysis (COA) for every manufacturing batch.
Using overseas partners, we arrange localized customs clearance, DDP shipping options, and safety stocking services to prevent global supply delays.
WS-23 features its cooling activity primarily on the front of the tongue and mouth cavity, having virtually no scent or taste profile. WS-3 offers a deeper cooling effect toward the throat and back of the mouth, with a very subtle mint undertone. Mixing the two creates a balanced cooling sensation.
Our discount pricing is built on high production efficiency. Operating at scale (annual capacity around 50,000 tons) allows us to buy precursors in bulk, run continuous chemical synthesis, and lower raw energy use per kilogram.
Yes, our WS series cooling agents can withstand temperatures up to 180°C - 220°C, making them highly stable for hard candy cooking, chewing gum base extrusion, and heat sterilization in food and beverage processing.
We provide full documentation, including GHS-compliant Safety Data Sheets (SDS), Certificates of Analysis (COA), heavy metal and solvent assay reports, allergen statements, FDA registry details, and REACH registration documents.
Bieyouth
